Tottenham head Coach,Mauricio Pochettino has revealed that Vertonghen and Harry Winks could both miss the north London derby against Arsenal due to hip injuries.
Eric Dier and Dele Alli are already sidelined but Spurs will have striker Harry Kane available for Saturday’s heavyweight clash at Wembley.
Spurs will run late fitness tests on Winks and Vertonghen but Pochettino is unsure whether Dier or Alli could be ready for Tuesday’s Champions League trip to Borussia Dortmund.
Ahead of saturday’s match, Spurs sit third in the Premier League after losing their last two games at Burnley and Chelsea to slip out of the title race and allow Arsenal to move four points behind them.
The race for Champions League qualification looks likely to go to the wire and Pochettino says Spurs will not lack motivation in the derby, having won five of their last seven home Premier League games against Arsenal.